If you know the maximum fuel consumption of the engine in GPH, then, go with this figure to be conservative (always better to err on the side of caution when plotting fuel consumption in a boat)
Then, use a GPS to figure out the max speed of your boat in MPH with the given load.
Then, you calculate for the amount of fuel you have on board, as well as the max consumption in GPH. This will give you the total for cruise time at full load, or WOT.
Based on cruise time, and your vessel's max speed in MPH, you can then calculate its maximum cruise range at WOT.
Since a boat is typically run at 75-90% throttle, fuel consumption will be a little less than what you calculate, which is a good thing. But you want to calculate for WOT, to account for heavier loads, running against current or wind, attitude of bow, drag, etc.
And when plotting fuel consumption for a trip, always remember the 3/3 rule. 1/3 to get where you're going, 1/3 for the return, and 1/3 for reserve.